I'm always tinkering, but I've gotten fairly comfortable with this UI in combat during a 25-man raid (my strongly preferred method of checking out UIs -- don't show me what your screen looks like while you're scratching your ass in Dalaran ). It can be a little difficult to tinker with your in-combat UI while you're in combat, but enough trial and error has gotten it to this point, mostly by trying to keep the center of the screen clear and not having anything pop up that blocks my view of myself or the ground around me. I have BigWigs set up to display its cooldowns on the right and its messages and distance warnings in the upper center. Scrolling combat text is on the left. X-Perl target and target of target are between the chat box and the Grid frames (I do the same with focus on the other side). That yellow-ish circle around me is Power Auras telling me that I have Surge of Light up and I have four seconds left to use it. The pinkish glow outside of that is Holy Concentration, which has six seconds left. I used to have the opacity set a lot higher, but it's more important to be able to see through those visuals. Each of those also have their own unique sound when they proc. 99% of my healing is done via Grid + Clique now. As any of you Grid users know, there is ton of flexibility with the Grid add-ons in terms of the information that you want conveyed to you and how you want Grid to do that. In my case the icons, dots, and numbers are telling me that Questiondead has a snobold on him and Prayer of Mending has bounced to Dwarr. Sangwyn, Dwarr, and Question have Renews ticking. Tryan is shielded, and Grid also confirms the BigWigs message that Tryan has three Impales. I just installed a fan update of Tell Me When. That's the four boxes to the right of the Grid frames. I have it set so that if I use Guardian Spirit, Circle of Healing, or my trinket, the appropriate icon disappears until its cooldown has expired. It's a great visual cue to tell me when I can use an item or a skill that has a cooldown longer than the GCD. Finally, good old Omen in the lower righthand corner keeps track of threat -- good to see the tanks at the top of it, followed by (shocker) a hunter (warlocks are still very good for that, too). By the way, that hunter "Korbane" is Corbain from back when we raided AQ20 with Wum Ba -- good guy.